منابع مشابه
Intercalation processes of copper complexes in DNA
The family of anticancer complexes that include the transition metal copper known as Casiopeínas® shows promising results. Two of these complexes are currently in clinical trials. The interaction of these compounds with DNA has been observed experimentally and several hypotheses regarding the mechanism of action have been developed, and these include the generation of reactive oxygen species, p...
متن کاملStructure of DNA-cationic liposome complexes: DNA intercalation in multilamellar membranes in distinct interhelical packing regimes.
Cationic liposomes complexed with DNA (CL-DNA) are promising synthetically based nonviral carriers of DNA vectors for gene therapy. The solution structure of CL-DNA complexes was probed on length scales from subnanometer to micrometer by synchrotron x-ray diffraction and optical microscopy. The addition of either linear lambda-phage or plasmid DNA to CLs resulted in an unexpected topological tr...
متن کاملOrganization of DNA in chromatin ( chromatin structure / intercalation / DNA - kinking )
Conformational changes in DNA that accompany drug intercalation have led us to ask if DNA first bends or "kinks" to accept an intercalative drug or dye. Kinking is made possible by altering the normal C2' endo deoxyribose sugar ring puckering in B DNA to a mixed sugarpuckering pattern of the type C3' endo (3'-5') C2' endo and partially unstacking base-pairs. A kinking scheme such as this would ...
متن کاملReversible Intercalation of Fluoride-Anion Receptor Complexes in Graphite
Reversible Intercalation of Fluoride-Anion Receptor Complexes in Graphite William C. West,* Jay F. Whitacre,* Nicole Leifer, Steve Greenbaum,* Marshall Smart,* Ratnakumar Bugga,* Mario Blanco, and S. R. Narayanan* Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California 91109, USA Hunter College, City University of New York, New York, New York 10021, USA California In...
متن کاملFast photoinduced electron transfer through DNA intercalation.
We report evidence for fast photoinduced electron transfer mediated by the DNA helix that requires metal complexes that are avid intercalators of DNA. Here the donor bis(phenanthroline)(dipyridophenazine)ruthenium(II) [Ru(phen)2dppz2+] and acceptor bis(9,10-phenanthrenequinone diimine)(phenanthroline)rhodium(III) [Rh(phi)2phen3+] intercalate into DNA with Kb > 10(6) M-1. Luminescence quenching ...
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ژورنال
عنوان ژورنال: Nature
سال: 1977
ISSN: 0028-0836,1476-4687
DOI: 10.1038/269285a0